반응 #2324
ord-53468aff36b74b69af45a0218b9d4c73
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타to reach ambient temperature
- 2기타the organic phase separated
- 3기타dried
- 4기타(MgSO4), and removal of the solvent
- 5기타by evaporation
실험 절차
Acetyl chloride (3.95 ml) was added dropwise to a stirred solution of 4-amino1-benzylpiperidine (10.0 g) and triethylamine (7.7 ml) in dry dichloromethane (100 ml) at 4° C. The mixture was allowed to reach ambient temperature and stirred for 16 hours. Water was then added, the organic phase separated and dried (MgSO4), and removal of the solvent by evaporation gave 4-acetylamino-1-benzylpiperidine, 10.23 g, as a light brown solid which was used without further purification: NMR (CDCl3) δ 7.29(5H,m), 5.29(1H,b), 3.79(1H,m), 3.49(2H,s), 2.80(2H,dm), 2.12(2H,dt), 1.95(3H,s), 191(2H,dm), 1.46(2H,dq); m/e 233 (M+H)+.