반응 #2323985

반응 방정식

sodium bicarbonate

sodium triacetoxyborohydride

propionaldehyde

acetic acid

(4Z)-6-Iodo-4-{[(4-piperazin-1-ylphenyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione

→

title compound

수율 70.0%

(4Z)-6-Iodo-4-({[4-(4-propylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione

수율 70.0%

용매

methylene chloride

methylene chloride

N-methylpyrrolidinone

반응 조건

후처리

1. 1
   기타The organic layer is separated
2. 2
   기타dried

실험 절차

(4Z)-6-Iodo-4-{[(4-piperazin-1-ylphenyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione (47.4 mg, 0.1 mmol) is dissolved in N-methylpyrrolidinone (1 mL) and methylene chloride (0.3 mL), followed by addition of sodium triacetoxyborohydride (244 mg, 1.15 mmol), propionaldehyde (0.186 mL, 2.6 mmol) and acetic acid (0.15 mL, 2.6 mmol). After stirring at room temperature for 40 min, methylene chloride and saturated sodium bicarbonate solution were added. The organic layer is separated and dried to give 36 mg (70%) of the title compound as a yellow solid. MS (ESI) m/z 517 (M+H)+1.

출처