반응 #2323928

반응 방정식

4Z

(4Z)-6-Bromo-4-({[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}methylene)-isoquinoline-1,3(2H,4H)-dione

6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione

→

[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amine

(4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

용매

N,N-dimethylformamide

반응 조건

실험 절차

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, 3.0 g (92.0% yield) of light brown solid is obtained from 2.0 g (7.09 mmol) of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione and 1.63 g (7.8 mmol) of [3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amine and 25 mL of N,N-dimethylformamide: mp 206-207° C.; MS (ESI) m/z 459.0-461.0 (M+H)+1

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