반응 #2320113

반응 방정식

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine-4-ol

trifluoroacetic acid

→

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine

용매

CH2Cl2

반응 조건

후처리

1. 1
   온도refluxed for 24 hours
2. 2
   기타The phases were separated
3. 3
   세척the organic phase was washed with two portions of 10%-Na2CO3
4. 4
   건조dried (MgSO4)
5. 5
   여과filtered
6. 6
   기타evaporated to dryness

실험 절차

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine-4-ol (1.5 g) was dissolved trifluoroacetic acid (35 ml) and refluxed for 24 hours and then CH2Cl2 (200 ml) was added. The phases were separated and then the organic phase was washed with two portions of 10%-Na2CO3, dried (MgSO4), filtered and evaporated to dryness. Yield 1.5 g. MS m/z (relative intensity, 70 eV) 351 (M+, 27), 172 (9), 92 (11), 91 (bp), 65 (21).

출처