반응 #2314288

반응 방정식

potassium carbonate

1-(4′-hydroxyphenyl)-3-bromopropane

dihydropyran

→

1-(4′-(2-tetrahydropyranyloxy)phenyl)-3-bromopropane

용매

dichloromethane

반응 조건

후처리

1. 1
   온도to warm to room temperature
2. 2
   여과The solid is then filtered out
3. 3
   기타the solvents and residual DHP is removed in vacuo

실험 절차

To a solution of 1-(4′-hydroxyphenyl)-3-bromopropane 3B (3.56 g) in dichloromethane (11 mL) is added dihydropyran (2.3 mL). The reaction mixture is cooled to 0° C., and three drops of phosphorus oxychloride are added. The reaction mixture is stirred in the ice bath for a further two hours, then gradually allowed to warm to room temperature, where it is allowed to stir overnight. To the reaction mixture is then added potassium carbonate (3 g), and the reaction mixture is stirred an additional hour. The solid is then filtered out, and the solvents and residual DHP is removed in vacuo.

출처