반응 #2314287

반응 방정식

3-(4-hydroxyphenyl)-1-propanol

tetrabromomethane

water

→

1-(4′-hydroxyphenyl)-3-bromopropane

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   workup.ADDITIONis added
2. 2
   추출extracted with ethyl acetate
3. 3
   세척The combined organic layers are washed with brine
4. 4
   건조dried over magnesium sulfate
5. 5
   농축The solution is concentrated in vacuo

실험 절차

To a solution of 3-(4-hydroxyphenyl)-1-propanol 3A (4.0 g) and tripohenylphosphine (7.96 g) in anhydrous dichloromethane (77 mL), cooled to 0° C., is added, dropwise, a solution of tetrabromomethane (9.59 g) in anhydrous dichloromethane (15.4 mL). The reaction mixture gradually warmed to room temperature and allowed to stir overnight. The solution is then poured into water and extracted with ethyl acetate. The combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

출처