반응 #2314284

반응 방정식

ketone

4-Methoxyphenyl (4-(4-methyl-3-pentenyl)-3-cyclohexenyl)methyl ketone

potassium hydroxide

hydrazine hydrate

→

2-(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)ethyl-4-methoxybenzene

용매

diethylene glycol

반응 조건

후처리

1. 1
   온도150° C., all for 30 minutes each, then cooled to room temperature
2. 2
   추출The reaction mixture is extracted between ethyl ether and water
3. 3
   세척the combined organic layers are washed with brine
4. 4
   건조dried over magnesium sulfate
5. 5
   농축The solution is concentrated in vacuo
6. 6
   여과the product is purified by silica gel filtration

실험 절차

To a solution of ketone 2E (R=4-Methyl-3-pentenyl) (10 g) in diethylene glycol (30 mL) is added potassium hydroxide (4.3 g) and hydrazine hydrate (4.5 mL). The solution is sequentially heated to 100° C., 125° C., and 150° C., all for 30 minutes each, then cooled to room temperature. The reaction mixture is extracted between ethyl ether and water, and the combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo, and the product is purified by silica gel filtration using 20:1 hexanes:ethyl acetate as an eluent.

출처