반응 #2314283

반응 방정식

HCl

acid chloride

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetyl chloride

anisole

→

4-Methoxyphenyl (4-(4-methyl-3-pentenyl)-3-cyclohexenyl)methyl ketone

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   온도cooled in an ice/ethanol bath
2. 2
   workup.STIRRINGstirred for 30 minutes
3. 3
   추출The aqueous layer is extracted with dichloromethane
4. 4
   세척the combined organic layers are sequentially washed with water, sodium bicarbonate, and water
5. 5
   건조dried over magnesium sulfate
6. 6
   농축The solution is concentrated in vacuo

실험 절차

A solution of acid chloride 2C (R=4-Methyl-3-pentenyl) (10 g) in anhydrous dichloromethane (100 mL) is added dropwise to a mixture of ferric chloride (7.8 g) and anisole 2D (4.5 g) in dichloromethane (175 mL), cooled in an ice/ethanol bath. The resulting mixture is gradually warmed to room temperature and stirred overnight. The mixture is poured into 25% HCl (150 mL) and stirred for 30 minutes. The aqueous layer is extracted with dichloromethane, and the combined organic layers are sequentially washed with water, sodium bicarbonate, and water, then dried over magnesium sulfate. The solution is concentrated in vacuo.

출처