반응 #2314281

반응 방정식

hydrochloric acid

sodium hydroxide

nitrile

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

water

→

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetic acid

용매

hydrogen peroxide

반응 조건

후처리

1. 1
   온도at reflux overnight
2. 2
   추출The acid product is extracted with ethyl acetate
3. 3
   세척the combined organic layers are washed with brine
4. 4
   건조dried over magnesium sulfate
5. 5
   농축The solution is concentrated in vacuo

실험 절차

To a solution of sodium hydroxide (10.5 g) in water (150 mL) and 30% hydrogen peroxide (50 mL) is added the nitrile 2A (R=4-Methyl-3-pentenyl) (10 g). The reaction mixture is stirred at reflux overnight. The reaction is then cooled to room temperature, and poured into a mixture of ice (30 g) and hydrochloric acid (22 mL). The acid product is extracted with ethyl acetate, and the combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

출처