반응 #2314280

반응 방정식

water

tosylate

potassium cyanide

→

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

용매

dimethylsulfoxide

반응 조건

후처리

1. 1
   온도The reaction mixture is cooled to room temperature
2. 2
   추출extracted with hexane
3. 3
   건조The combined organic layers are dried over magnesium sulfate
4. 4
   농축the solution is concentrated in vacuo

실험 절차

To a solution of tosylate 1H (R=4-Methyl-3-pentenyl) (20 g) in dimethylsulfoxide (178 mL) is added potassium cyanide (19.4 g). The reaction mixture is heated to 100° C., and the reaction mixture is stirred at that temperature for three hours. The reaction mixture is cooled to room temperature, added to water (300 mL), and extracted with hexane. The combined organic layers are dried over magnesium sulfate and the solution is concentrated in vacuo.

출처