반응 #2314279

반응 방정식

bromopentane

→

2-Pentyl-1,3-butadiene

용매

ammonium chloride

반응 조건

후처리

1. 1
   온도gradually warming to room temperature
2. 2
   workup.STIRRINGThe reaction mixture is stirred for 10 minutes, during which time the aqueous layer
3. 3
   추출The reaction mixture is then extracted with hexanes
4. 4
   건조the combined organic layers are dried over magnesium sulfate
5. 5
   기타The solvent is carefully removed by rotary evaporation
6. 6
   기타to give 17 g of a colorless, malodorous liquid

실험 절차

To a flask containing cuprous bromide (1.0 g) is added bromopentane (23 g) and tetrahydrofaran (154 mL). The solution is cooled to 0° C., and the Grignard reagent 1B is added. The reaction is stirred overnight, gradually warming to room temperature. To the solution is then added 30 mL saturated ammonium chloride. The reaction mixture is stirred for 10 minutes, during which time the aqueous layer turns blue. The reaction mixture is then extracted with hexanes, and the combined organic layers are dried over magnesium sulfate. The solvent is carefully removed by rotary evaporation to give 17 g of a colorless, malodorous liquid.

출처