반응 #2314278

반응 방정식

tetrabromomethane

3-(4-hydroxyphenyl)-1-propanol

triphenylphosphine

→

3-(4-hydroxyphenyl)-1-bromopropane

수율 62.0%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   추출extracted with dichloromethane
2. 2
   세척the organic layer was washed with water
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   기타The solvent was removed in vacuo
5. 5
   기타the crude reaction mixture
6. 6
   여과was filtered through silica gel
7. 7
   세척eluting with 10% ethyl acetate in hexane

실험 절차

A solution of tetrabromomethane (1.125 eq.) in dichloromethane (0.5 ml/mole) was added dropwise to the solution of the commercially available 3-(4-hydroxyphenyl)-1-propanol 1B (1 eq.) and triphenylphosphine (1.125 eq.) in dichloromethane at 0° C. The reaction mixture was stirred at room temperature for 2 days, extracted with dichloromethane, and the organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed in vacuo. the crude reaction mixture was filtered through silica gel, eluting with 10% ethyl acetate in hexane, to give 3-(4-hydroxyphenyl)-1-bromopropane 2 as a brown oil in 62% yield.

출처