반응 #2307620

반응 방정식

N-triisopropylsilylpyrrole

3-bromo-1-ethynylbenzene

→

3-[(3-bromophenyl)ethynyl]-1-(triisopropylsilyl)-1H-pyrrole

용매

CH3CN

triethylamine

반응 조건

후처리

1. 1
   기타the solvent is evaporated on a rotary evaporator
2. 2
   기타The crude material is purified by flash

실험 절차

A solution of N-triisopropylsilylpyrrole (3.49 g, 1 mmol), 3-bromo-1-ethynylbenzene (1.81 g, 1 mmol), Pd(PPh3)4 (800 mg) and CuI (185 mg) in CH3CN (15 ml) and triethylamine (35 ml) is refluxed for 5 h. The reaction mixture is cooled to room temperature and the solvent is evaporated on a rotary evaporator. The crude material is purified by flash chromatographied (silica gel, 100% hexane) to afford 3-[(3-bromophenyl)ethynyl]-1-(triisopropylsilyl)-1H-pyrrole (2.7 g, 85%) as a clear oil.

출처