반응 #2307437

반응 방정식

(6-o-tolylpyridin-3-yl)methanol

hydrobromic acid

→

product

수율 95.0%

5-(Bromomethyl)-2-o-tolylpyridine hydrobromide

수율 95.0%

반응 조건

후처리

1. 1
   온도to reflux for 64 h
2. 2
   온도The reaction mixture was partially cooled
3. 3
   기타excess hydrobromic acid was removed by vacuum distillation (110° C. @ 2 Torr) until a tan solid residue
4. 4
   workup.DISTILLATIONDistillation
5. 5
   여과filtered
6. 6
   기타dried under a nitrogen stream

실험 절차

A solution of 4.49 g (22.5 mmol) of (6-o-tolylpyridin-3-yl)methanol in 75 mL of 48% hydrobromic acid was heated to reflux for 64 h. The reaction mixture was partially cooled and excess hydrobromic acid was removed by vacuum distillation (110° C. @ 2 Torr) until a tan solid residue remained in the flask. Distillation was carried out using a large KOH pellet trap placed between the distillation apparatus and the vacuum pump. The solid residue was slurried in diethyl ether, filtered and dried under a nitrogen stream to give 7.38 g of product, 95% yield.

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