반응 #2304278

반응 방정식

methyl 5-bromo-2-furoate

hydrochloric acid

5-trimethylsilyl-2-methylphenol

Intermediate 3

5-trimethylsilyl-2-methylphenol

potassium tert-butoxide

→

title compound

수율 57.0%

Methyl 5-[2-methyl-5-(trimethylsilyl)phenoxy]furan-2-carboxylate

수율 57.0%

용매

water

THF

반응 조건

후처리

1. 1
   온도the reaction heated
2. 2
   온도at reflux for 1.5 hours
3. 3
   농축concentrated under reduced pressure
4. 4
   온도heated at 85° C. for 18 hours
5. 5
   온도to cool to room temperature
6. 6
   추출The mixture was extracted with diethyl ether (3×30 mL)
7. 7
   건조the combined organic extracts were dried (magnesium sulphate)
8. 8
   농축concentrated under reduced pressure
9. 9
   기타purified by column chromatography (SiO2; light petroleum to 95:5 light petroleum-diethyl ether)

실험 절차

To a solution of 5-trimethylsilyl-2-methylphenol (Intermediate 3; 653 mg, 3.6 mmol) in THF was added potassium tert-butoxide (407 mg, 3.6 mmol) and the reaction heated at reflux for 1.5 hours. The resulting solution was allowed to cool to room temperature and concentrated under reduced pressure. The residue was taken up in dimethyl sulphoxide (10 mL), treated with methyl 5-bromo-2-furoate (632 mg, 3.1 mmol) and heated at 85° C. for 18 hours. The dark brown mixture was allowed to cool to room temperature, diluted with water (10 mL) and then acidified by the addition of hydrochloric acid (1 M). The mixture was extracted with diethyl ether (3×30 mL) and the combined organic extracts were dried (magnesium sulphate), concentrated under reduced pressure and purified by column chromatography (SiO2; light petroleum to 95:5 light petroleum-diethyl ether) to give the title compound as a colourless oil (534 mg, 57%). Rf=0.21 (9:1 light petroleum-diethyl ether). LCMS Rt=4.9 mins, m/z=305 (MH+).

출처