반응 #2304

반응 방정식

product

4-[4-(4-pyridyl)-piperazin-1-yl]anisole

water

ammonia

→

4-[4-(4-pyridyl)piperazin-1-yl]phenol

수율 95.6%

용매

hydrobromic acid

반응 조건

후처리

1. 1
   온도The solution was cooled
2. 2
   여과The precipitate was filtered
3. 3
   세척washed with water
4. 4
   기타dried

실험 절차

The product from step (i) (1.5 g) in concentrated hydrobromic acid (30 ml) was heated under argon at 130°-135° C. for 21/2 hours. The solution was cooled, poured into water (150 ml) and basified with aqueous ammonia. The precipitate was filtered, washed with water and dried to give 4-[4-(4-pyridyl)piperazin-1-yl]phenol (1.36 g) as a solid: m.p. 310°-312° C.; NMR(d6DMSO) δ 8.2(2H,d); 6.8(4H,m); 6.66(2H,d); 3.45(4H,m); 3.08(4H,m).

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