반응 #2300773

반응 방정식

Water

sodium hydride

N-(4-isopropylphenyl)acetamide

butyl bromide

→

butyl(4-isopropylphenyl)amine

용매

dimethylformamide

반응 조건

후처리

1. 1
   온도cooling
2. 2
   추출the mixture was extracted with ethyl acetate
3. 3
   세척The organic layer was washed
4. 4
   기타dried
5. 5
   농축concentrated under reduced pressure
6. 6
   workup.ADDITION4N Hydrochloric acid (13 mL) was added to the residue
7. 7
   온도the mixture was refluxed for 7 hr
8. 8
   workup.ADDITIONWater was added to the reaction mixture
9. 9
   추출the mixture was extracted with ethyl acetate
10. 10
    세척The organic layer was washed
11. 11
    기타dried
12. 12
    농축concentrated under reduced pressure

실험 절차

To a solution of N-(4-isopropylphenyl)acetamide (1.8 g) in dimethylformamide (18 mL) was added, under ice-cooling, 60% sodium hydride (0.44 g). Further, butyl bromide (1.4 mL) was added and the mixture was stirred overnight. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed, dried and concentrated under reduced pressure. 4N Hydrochloric acid (13 mL) was added to the residue and the mixture was refluxed for 7 hr. Water was added to the reaction mixture followed by neutralization and the mixture was extracted with ethyl acetate. The organic layer was washed, dried and concentrated under reduced pressure to give butyl(4-isopropylphenyl)amine (1.8 g).

출처