반응 #2298625

반응 방정식

ammonium formate

3-(formylamino)-2-thiophenecarboxylic acid methyl ester

3-(Formylamino)-2-thiophenecarboxylic acid methyl ester

→

3H-thieno[3,2-d]pyrimid-4-one

수율 63.4%

용매

formamide

반응 조건

후처리

1. 1
   기타The precipitate that formed
2. 2
   여과was collected by vacuum filtration

실험 절차

To a solution of ammonium formate (9.4 g, 0.15 mol) in formamide (14 mL) at 150° C. was added 3-(formylamino)-2-thiophenecarboxylic acid methyl ester (81, 5.2 g, 28 mmol) as a solid in small portions. The resulting solution was heated at 150° C. for 4 hours and then allowed to stand at room temperature for 12 hours. The precipitate that formed was collected by vacuum filtration to give 3H-thieno[3,2-d]pyrimid-4-one (2.7 g, 63% yield) as white needles.

출처