반응 #2298620

반응 방정식

3H-thieno[3,2-d]pyrimid-4-one

3H-Thieno[3,2-d]pyrimid-4-one

bromine

sodium bicarbonate

→

7-bromo-3H-thieno[3,2-d]pyrimid-4-one

수율 64.0%

용매

acetic acid

acetic acid

반응 조건

후처리

1. 1
   온도The reaction mixture was heated
2. 2
   온도at reflux for 8 hours
3. 3
   여과The solid product was collected by vacuum filtration

실험 절차

To a solution of 3H-thieno[3,2-d]pyrimid-4-one (82, 0.98 g, 6.4 mmol) in acetic acid (3.4 mL) was added a solution of bromine (1 mL) in acetic acid (3 mL). The reaction mixture was heated at reflux for 8 hours. The resulting suspension was allowed to cool to room temperature and then poured into a saturated aqueous solution of sodium bicarbonate to neutralize. The solid product was collected by vacuum filtration to give 7-bromo-3H-thieno[3,2-d]pyrimid-4-one (0.94 g, 64% yield) as a pale yellow solid.

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