반응 #2298617

반응 방정식

(7-methylthieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride

(7-Methylthieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride

3-pyridinecarboxaldehyde

→

3-pyridinecarboxaldehyde(7-methylthieno[3,2-d]pyrimidin-4-yl)hydrazone

수율 71.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for 4 hours
3. 3
   여과the solid product was collected by vacuum filtration
4. 4
   기타recrystallized from methanol

실험 절차

A suspension of (7-methylthieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride (5, 1.7 g, 7.9 mmol) and 3-pyridinecarboxaldehyde(1.1 g, 10.3 mmol) in ethanol (30 mL) was heated at reflux for 4 hours. After cooling to room temperature, the solid product was collected by vacuum filtration and recrystallized from methanol to yield 3-pyridinecarboxaldehyde(7-methylthieno[3,2-d]pyrimidin-4-yl)hydrazone (1.5 g, 71% yield) as white needles.

출처