반응 #2298616

반응 방정식

4-chloro-7-methylthieno[3,2-d]pyrimidine

4-Chloro-7-methylthieno[3,2-d]pyrimidine

hydrazine monohydrate

→

(7-methylthieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride

수율 88.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for 1 hour
3. 3
   여과the solid product was collected by vacuum filtration

실험 절차

A suspension of 4-chloro-7-methylthieno[3,2-d]pyrimidine (4, 3.1 g, 17 mmol) and hydrazine monohydrate (3.5 mL, 72 mmol) in ethanol (34 mL) was heated at reflux for 1 hour. After cooling to room temperature, the solid product was collected by vacuum filtration to give (7-methylthieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride (3.2 g, 88% yield) as a white solid.

출처