반응 #2298614

반응 방정식

ammonium formate

3-(formylamino)-4-methyl-2-thiophenecarboxylic acid methyl ester

3-(Formylamino)-4-methyl-2-thiophenecarboxylic acid methyl ester

→

7-methyl-3H-thieno[3,2-d]pyrimid-4-one

수율 84.0%

용매

formamide

반응 조건

후처리

1. 1
   기타The precipitate that formed
2. 2
   여과was collected by vacuum filtration

실험 절차

To a solution of ammonium formate (5.1 g, 81 mmol) in formamide (25 mL) at 150° C. was added 3-(formylamino)-4-methyl-2-thiophenecarboxylic acid methyl ester (2, 5.0 g, 25 mmol) as a solid in small portions. The resulting solution was heated at 150° C. for 5 hours and then allowed to stand at room temperature for 12 hours. The precipitate that formed was collected by vacuum filtration to give 7-methyl-3H-thieno[3,2-d]pyrimid-4-one (3.4 g, 84% yield) as white needles.

출처