반응 #2290193

반응 방정식

5-iodothiophene-3-carboxylic acid

iodomethane

potassium carbonate

DMF

→

title compound

수율 98.6%

Methyl 5-iodothiophene-3-carboxylate

수율 98.6%

용매

water

반응 조건

후처리

1. 1
   추출extracted with EtOAc
2. 2
   세척The extract was washed with brine
3. 3
   건조dried over MgSO4
4. 4
   농축concentrated
5. 5
   기타purified by silica gel column chromatography (hexane/EtOAc)

실험 절차

A mixture of 5-iodothiophene-3-carboxylic acid (3.48 g), iodomethane (2.92 g), potassium carbonate (2.84 g) and DMF (35 ml) was stirred at room temperature for 1 day. The reaction mixture was poured into water, and extracted with EtOAc. The extract was washed with brine, dried over MgSO4, concentrated and purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (3.62 g) as a white solid.

출처