반응 #2289763

반응 방정식

4-benzhydryloxypiperidine

methyl N-tert-butoxycarbonyl-5-formylpyrrole-2-carboxylate

sodium triacetoxyborohydride

→

5-(4-Benzhydryloxypiperidin-1-ylmethyl)pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

용매

dichloromethane

반응 조건

후처리

1. 1
   온도Then, the mixture was heated to a room temperature
2. 2
   workup.STIRRINGstirred overnight

실험 절차

Into a 100-mL three-neck flask, 1.1 g (4.0 mmol) of 4-benzhydryloxypiperidine synthesized in Production Example 1, 1.0 g (4.0 mmol) of methyl N-tert-butoxycarbonyl-5-formylpyrrole-2-carboxylate, and 20 mL of dichloromethane were fed under an argon atmosphere, and the internal temperature was cooled to 0° C. Thereinto, 1.3 g (6.1 mmol, 1.5 eq.) of sodium triacetoxyborohydride was added at an internal temperature of not higher than −5° C., and the mixture was stirred for 5 minutes at the same temperature. Then, the mixture was heated to a room temperature and stirred overnight.

출처