반응 #2288239

반응 방정식

(R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-3-cyclohexylpropanamide

K2CO3

H2O2

→

titled compound

수율 32.1%

(R)-4-(1-amino-3-cyclohexyl-1-oxopropan-2-ylamino)-2-(3-methylisothiazol-5-ylamino)benzamide

수율 32.1%

용매

DMSO

반응 조건

후처리

1. 1
   기타the mixture was purified by HPLC

실험 절차

To a solution of (R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-3-cyclohexylpropanamide (241 mg, 0.629 mmol) in DMSO (2 mL), K2CO3 (300 mg, 2.17 mmol) and H2O2 (50% aq., 1.00 mL) were added. After being stirred at 90 C for 10 min, the mixture was purified by HPLC to give the titled compound (81 mg). MS 402.4 (M+H); UV 204.7, 298.3 nm

출처