반응 #2286321

반응 방정식

(3,5-dibromo-4-bromomethyl-phenyl)-methanol

(3,5-Dibromo-4-bromomethyl-phenyl)-methanol

6-(4-bromomethyl-2,6-dichloro-benzyl)-4-isopropyl-pyridazin-3-one

6-(4-Bromomethyl-2,6-dichloro-benzyl)-4-isopropyl-pyridazin-3-one

→

acetonitrile

수율 78.0%

(2,6-Dibromo-4-hydroxymethyl-phenyl)-acetonitrile

수율 78.0%

반응 조건

후처리

1. 1
   기타This compound was prepared by a similar method to
2. 2
   기타The product was purified by flash chromatography
3. 3
   세척eluted with a gradient of 3:1 to 1:1 hexanes
4. 4
   기타The desired fractions were collected
5. 5
   농축concentrated under vacuum
6. 6
   기타to afford a solid which
7. 7
   기타was dried under high vacuum

실험 절차

This compound was prepared by a similar method to that described in Example 14, Step 5 except that (3,5-dibromo-4-bromomethyl-phenyl)-methanol (58) was used in place 6-(4-bromomethyl-2,6-dichloro-benzyl)-4-isopropyl-pyridazin-3-one (54). The product was purified by flash chromatography using silica gel eluted with a gradient of 3:1 to 1:1 hexanes:ethyl acetate. The desired fractions were collected and concentrated under vacuum to afford a solid which was dried under high vacuum to afford 2,6-dibromo-4-hydroxymethyl-phenyl)-acetonitrile (59) (78%) as a yellow solid; EI(+)-HRMS m/z calcd for C9H7Br2NO (M 302.8894, found 302.8881. MW=304.9702, Exact Mass=302.8894

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