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(5R,7R)-4-chloro-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-7-yl 4-nitrobenzoate

tert-butyl (1′-benzyl-5-chlorospiro[indoline-3,4′-piperidine]-4-yl)methylcarbamate

→

(5R,7R)-4-(1′-benzyl-4-((tert-butoxycarbonylamino)methyl)-5-chlorospiro[indoline-3,4′-piperidine]-1-yl)-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-7-yl 4-nitrobenzoate

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실험 절차

(5R,7R)-4-(1′-benzyl-4-((tert-butoxycarbonylamino)methyl)-5-chlorospiro[indoline-3,4′-piperidine]-1-yl)-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-7-yl 4-nitrobenzoate was prepared by the procedures described in Example 1, Step 8, substituting (R)-4-chloro-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine with (5R,7R)-4-chloro-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-7-yl 4-nitrobenzoate, and substituting tert-butyl 5-chlorospiro[indoline-3,4′-piperidine]-1′-carboxylate with tert-butyl (1′-benzyl-5-chlorospiro[indoline-3,4′-piperidine]-4-yl)methylcarbamate. LCMS (APCI+) m/z 739, 741 [M+H]+; Rt=4.53 min.

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