반응 #2275764
ord-2b333eefa172451c81a4bb1a0f4e81ba
반응 방정식
{4-{3-[2-(3-trifluoromethyl-benzoylamino)-acetylamino]-azetidin-1-yl}-cyclohexyl)-carbamic acid tert-butyl ester
TFA
→
title compound
N-{[1-(4-Amino-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide TFA salt
반응물
시약
없음
용매
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타The solvent was removed
- 2기타the residue was dried in vacuo
실험 절차
A solution of {4-{3-[2-(3-trifluoromethyl-benzoylamino)-acetylamino]-azetidin-1-yl}-cyclohexyl)-carbamic acid tert-butyl ester (less polar isomer, as prepared in the previous step 5.6 g, 11.2 mmol) in DCM 10 mL and TFA (10 mL) was stirred for 4 hours at room temperature. The solvent was removed and the residue was dried in vacuo to afford the title compound as colorless oil.