반응 #2275763

ord-b544960175bb4523b3540ddba5814566

반응 방정식

CC(C)(C)OC(=O)NC1CCC(=O)CC1
(4-oxo-cyclohexyl)-carbamic acid tert-butyl ester
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide
CC(C)(C)OC(=O)NC1CCC(N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1
title compounds
CC(C)(C)OC(=O)NC1CCC(N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1
{4-{3-[2-(3-Trifluoromethyl-benzoylamino)-acetylamino]-azetidin-1-yl}-cyclohexyl)-carbamic acid tert-butyl ester

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compounds were prepared as white solids from the reductive amination of (4-oxo-cyclohexyl)-carbamic acid tert-butyl ester (Asta) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08324186B2uspto-grants-2012_12