반응 #2275734

ord-cafae10d3aa549dcaff1f057ffc17ccc

반응 방정식

O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide
O=C1CCC(n2cnccc2=O)CC1
3-(4-oxo-cyclohexyl)-3H-pyrimidin-4-one
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(n3cnccc3=O)CC2)C1
title compounds
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(n3cnccc3=O)CC2)C1
N-({1-[4-(6-Oxo-6H-pyrimidin-1-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compounds were prepared as white solids from the reductive amination of 3-(4-oxo-cyclohexyl)-3H-pyrimidin-4-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08324186B2uspto-grants-2012_12