반응 #2275727

반응 방정식

1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1H-pyridin-2-one

HCl

sodium bicarbonate

→

title compound

1-(4-Oxo-cyclohexyl)-1H-pyridin-2-one

용매

acetone

반응 조건

후처리

1. 1
   기타The solvent was removed in vacuo and residue
2. 2
   기타partitioned between ethyl acetate and water
3. 3
   세척The organic layer was washed with brine
4. 4
   건조dried over anhydrous Na2SO4
5. 5
   여과filtered
6. 6
   농축concentrated

실험 절차

A solution of 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1H-pyridin-2-one (as prepared in the previous step, ˜300 mg, 1.28 mmol)) in acetone (10 mL) was treated with 1N HCl (2 mL) at room temperature for 4 hours. The reaction was worked up with saturated sodium bicarbonate to adjust the pH to neutral. The solvent was removed in vacuo and residue partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous Na2SO4, filtered, concentrated to afford the title compound as white solid.

출처