반응 #2273674

반응 방정식

methyl-2-(N-benzoylamino)methyl-3-oxobutyrate

NEt3

→

title compound

수율 90.0%

methyl (2S,3R)-2-(N-benzoylamino)methyl-3-hydroxybutyrate

수율 90.0%

용매

methylene chloride

반응 조건

후처리

1. 1
   기타The solvent was removed by evaporation under reduced pressure
2. 2
   기타the residue was purified by column chromatography

실험 절차

In a 100 ml autoclave was put a solution of 2.5 g (10 mmol) of methyl-2-(N-benzoylamino)methyl-3-oxobutyrate and 173 mg (0.102 mmol) of Ru2Cl4((R)-BINAP)2.NEt3 in 17.5 ml of methylene chloride, and the mixture was stirred at 50° C. under a hydrogen pressure of 10000 kPa for 20 hours. The solvent was removed by evaporation under reduced pressure, and the residue was purified by column chromatography to furnish 2.25 g (90%) of the title compound. Optical purity: 98%e.e.

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