반응 #2273286

반응 방정식

4-bromo-5-(2-imidazolin-2-ylamino)benzimidazole

Br2

NH3

→

desired product

수율 86.0%

4,6-Dibromo-5-(2-imidazolin-2-ylamino)Benzimidazole

수율 86.0%

용매

AcOH

반응 조건

후처리

1. 1
   기타Reaction mixture
2. 2
   농축was concentrated in vacuo
3. 3
   기타yielding a dark oily residue, which

실험 절차

To a solution of 4-bromo-5-(2-imidazolin-2-ylamino)benzimidazole (0.2 g, 0.7 mmol) in 10 ml AcOH was added 200 mg of Hg(OAc)2 and few drops of Br2. Reaction mixture was concentrated in vacuo, yielding a dark oily residue, which was subjected to silica gel column chromatography (NH3 sat'd 30% MeOH/EtOAc) to provide 210 mg (0.58 mmol, 86%) of the desired product. The product obtained was converted to the fumarate salt and recrystallized from EtOH to afford 0.051 g (14%) of the product as a white solid.

출처