반응 #2271678

반응 방정식

6-fluoro-3-(4-piperidinyl)-1H-indazole

K2CO3

1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone

acetonitrile

→

desired product

수율 80.8%

1-[4-[3-[4-(6-Fluoro-1H-indazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]-ethanone

수율 80.8%

용매

water

반응 조건

후처리

1. 1
   기타the resulting white solid, which precipitated from solution
2. 2
   기타was collected

실험 절차

A stirred mixture of 6-fluoro-3-(4-piperidinyl)-1H-indazole (3.5 g, 16 mmol). K2CO3 (2.2 g). 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone (3.8 g, 16 mmol) and acetonitrile (90 ml) was refluxed for 16 hours. The reaction was poured into water and the resulting white solid, which precipitated from solution, was collected to afford 5.5 g of the desired product. The compound was recrystallized from dimethylformamide (twice) to afford 3.0 g (44%) of 1-[4-[3-[4-(6-fluoro-1H-indazol-3-yl)-1-piperidinyl]propoxy]-methoxyphenyl]ethanone as a white solid, m.p.=202°-204° C.

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