반응 #2271674

반응 방정식

3-(4-piperidinyl)-1H-indazole

1-[4-(4-bromobutoxy]-3-methoxyphenyl]ethanone

K2CO3

acetonitrile

→

1-[4-[4- [4-(1H-indazol-3-yl)-1-piperidinyl]-butoxy]-3-methoxyphenyl]ethanone

용매

water

반응 조건

후처리

1. 1
   온도refluxed for 6 hours
2. 2
   기타the resulting yellow solid that formed
3. 3
   기타was collected in afford 5.3 g of product
4. 4
   기타The compound was recrystallized from acetonitrile

실험 절차

A mixture of 3-(4-piperidinyl)-1H-indazole (3.2 g, 16 mmol, 1-[4-(4-bromobutoxy]-3-methoxyphenyl]ethanone (5.0 g, 16 mmol). K2CO3 (2.2 g) and acetonitrile (100 ml) was stirred and refluxed for 6 hours. The reaction was poured into water, and the resulting yellow solid that formed was collected in afford 5.3 g of product. The compound was recrystallized from acetonitrile and then from ethyl acetate to yield 3.0 g (45%) of a slightly yellow solid of 1-[4-[4- [4-(1H-indazol-3-yl)-1-piperidinyl]-butoxy]-3-methoxyphenyl]ethanone, m.p.=133°-135° C.

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