반응 #2267069

반응 방정식

3

3-Methyl-1-(4-nitrophenyl)-6-methoxyisochroman

sodium hydroxide

HCl

→

crude product

1-Hydroxy-3-methyl-1-(4-nitrophenyl)-6-methoxyisochroman

용매

DMSO

DMF

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate three times
2. 2
   세척The combined organic phase was washed with water in order
3. 3
   기타to remove DMF
4. 4
   건조dried over Na2SO4
5. 5
   기타Removal of the solvent

실험 절차

A solution of 3 (1.3 g) in 4 ml of DMSO and 24 ml of DMF was cooled to 8-12° C. and air was passed through the mixture. To the solution was added 1.2 ml of 50% aqueous sodium hydroxide in one portion and the resulting mixture was stirred for 5 hours. HCl (1 N) was added, and extracted with ethyl acetate three times. The combined organic phase was washed with water in order to remove DMF, dried over Na2SO4. Removal of the solvent afforded syrup crude product (1.6 g), which was used directly for the next step.

출처