반응 #2267067

반응 방정식

3-methoxyphenylacetone

NaBH4

→

desired product 2

수율 100.0%

1-(3-Methoxyphenyl)-2-propyl alcohol

수율 100.0%

용매

methanol

반응 조건

후처리

1. 1
   추출It was extracted with CHCl3 three times
2. 2
   세척The combined organic phase was washed with brine
3. 3
   건조dried over Na2SO4
4. 4
   기타Removal of the solvent
5. 5
   기타afforded the crude product
6. 6
   기타Purification of the crude product

실험 절차

To a solution of 3-methoxyphenylacetone (1, 1.0 g) in methanol (30 ml) was added NaBH4 (360 mg) in portions in the period of 20 min at 0° C. The resulting solution was stirred at such temperature for another 40 min. No more starting materials were detected from TLC. Ice water was added to the reaction slowly. It was extracted with CHCl3 three times. The combined organic phase was washed with brine, and dried over Na2SO4. Removal of the solvent afforded the crude product. Purification of the crude product by using a silica gel column gave the desired product 2 (1.01 g, 100%).

출처