반응 #2267065

반응 방정식

toluene

toluene

Dimethyl sulfoxide

5-azacytidine

5-azacytidine

DMSO

→

DMSO Toluene

반응 조건

후처리

1. 1
   기타preheated to approximately 90° C., in separate 100-mL beakers
2. 2
   workup.DISSOLUTIONto dissolve to a clear solution
3. 3
   기타preheated to approximately 50° C.
4. 4
   workup.ADDITIONwas added to the solution
5. 5
   여과The product was collected by vacuum filtration as white crystals
6. 6
   기타to air dry

실험 절차

Dimethyl sulfoxide (DMSO) was used as the primary solvent to solubilize Form I of 5-azacytidine and toluene was used as the co-solvent as follows. Approximately 250 mg of 5-azacytidine was dissolved with approximately 5 mL of DMSO, preheated to approximately 90° C., in separate 100-mL beakers. The solids were allowed to dissolve to a clear solution. Approximately 45 mL of toluene, preheated to approximately 50° C., was added to the solution and the resultant solution was mixed. The solution was covered and allowed to equilibrate at ambient conditions. The product was collected by vacuum filtration as white crystals using a Buchner funnel. The collected product was allowed to air dry.

출처