반응 #2266

반응 방정식

6-(4-chlorophenyl)-4,5-dihydropyridazinone

acetic acid

bromine

→

6-(4-chlorophenyl)pyridazinone

수율 93.1%

용매

water

반응 조건

후처리

1. 1
   온도the mixture was heated at 60°-70° C. for 3 h
2. 2
   온도The resulting mixture was cooled
3. 3
   여과The resulting white solid was filtered
4. 4
   기타dried

실험 절차

To a solution of 6-(4-chlorophenyl)-4,5-dihydropyridazinone (11.75 g) and glacial acetic acid (100 ml) was added dropwise 3 ml of bromine and the mixture was heated at 60°-70° C. for 3 h. The resulting mixture was cooled and slowly poured into 400 ml of cold water. The resulting white solid was filtered and dried to yield 10.83 g (89%) of 6-(4-chlorophenyl)pyridazinone.

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