반응 #2264759

반응 방정식

Intermediate 2

1-Phenyl-1H-imidazo[4,5-c]pyridine

→

desired compound

수율 80.0%

1-phenyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

수율 80.0%

용매

AcOH

반응 조건

후처리

1. 1
   기타at 100° C
2. 2
   기타The crude reaction mixture
3. 3
   농축was concentrated
4. 4
   기타purified on 12 g SiO2 column with 0-10% NH3/MeOH CH2Cl2

실험 절차

A solution of Intermediate 2 (111 mg, 0.569 mmol) in AcOH (15 ml) was passed through a Rh/C catalyst cartridge on an H-Cube hydrogenation apparatus at a pressure of 80 bar and a flow rate of 1 ml/min at 100° C. The reaction was looped through the apparatus for 2 h. The crude reaction mixture was concentrated and purified on 12 g SiO2 column with 0-10% NH3/MeOH CH2Cl2 to give the desired compound (90 mg, 80%). MS (ESI): mass calcd. for C12H13N3, 199.3. m/z found, 200.2 [M+H]+.

출처