반응 #2263019

반응 방정식

2,6-Difluoro-3-(oxiran-2-yl)benzonitrile

(S)-4-N-BOC-2-hydroxymethylpiperazine

→

title compound

tert-butyl (3S)-4-[2-(3-cyano-2,4-difluorophenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

용매

ethanol

반응 조건

후처리

1. 1
   온도The reaction mixture was cooled
2. 2
   기타evaporated dryness
3. 3
   기타The residue was purified by chromatography through a 120 g Redi-sep column
4. 4
   세척eluting with 5% MeOH/95% EtOAc

실험 절차

2,6-Difluoro-3-(oxiran-2-yl)benzonitrile (1.50 g, 8.28 mmol) and (S)-4-N-BOC-2-hydroxymethylpiperazine (2.40 g, 11.1 mmol) were suspended in ethanol (15 mL) then heated in a microwave apparatus for 30 min at 150° C. The reaction mixture was cooled and evaporated dryness. The residue was purified by chromatography through a 120 g Redi-sep column eluting with 5% MeOH/95% EtOAc to yield the title compound LC-MS: M+1=398.

출처