반응 #2254973

반응 방정식

NaN3

NH4Cl

benzyl 4-cyanopiperidine-1-carboxylate

→

title compound

수율 19.3%

Benzyl 4-(1H-tetrazol-5-yl)piperidine-1-carboxylate

수율 19.3%

용매

DMF

반응 조건

후처리

1. 1
   기타The reaction mixture was quenched with 10% aqueous citric acid solution
2. 2
   추출extracted with EtOAc
3. 3
   건조dried over anhydrous sodium sulphate
4. 4
   농축concentrated under reduced pressure

실험 절차

NaN3 (1.7 g, 26.14 mmol) and NH4Cl (1.75 g, 32.7 mmol) were added to the solution of benzyl 4-cyanopiperidine-1-carboxylate (1.6 g, 26.14 mmol) in DMF (16 mL) and stirring was continued at 90° C. for 24 h. The reaction mixture was quenched with 10% aqueous citric acid solution, extracted with EtOAc, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 1.45 g of the title compound.

출처