반응 #2254200

ord-55d22e6600154d1b8fa38d6c3fc1a3b3

반응 방정식

CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride
OCC(O)CO
glycerol
→
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
Apomorphine

반응물

CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride
—
sodium carboxymethylcellulose
OCC(O)CO
glycerol

시약

없음

용매

O
Water

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    workup.ADDITIONThe resulting mixture is mixed thoroughly (i.e.
  2. 2
    기타to form a hydrogel
  3. 3
    workup.ADDITIONcontaining

실험 절차

The particulate apomorphine is combined with sodium carboxymethylcellulose and glycerol. The resulting mixture is mixed thoroughly (i.e., using a vacuum mixer) and homogenized. Water is added to the mixture (with extensive mixing) to form a hydrogel containing suspended nanoparticles of apomorphine hydrochloride.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09044475B2uspto-grants-2015_06