반응 #2254171

반응 방정식

sodium borohydride

ethanol

Ethyl 7-hydroxychromen-4-one-2-carboxylate

calcium chloride

Sodium borohydride

→

2-methoxy-7-hydroxy-4H-chromen-4-one

반응 조건

후처리

1. 1
   온도again cooled
2. 2
   workup.STIRRINGThe mixture is stirred overnight at RT

실험 절차

Ethyl 7-hydroxychromen-4-one-2-carboxylate (2 g, 8.538 mmol) and granulated and dried calcium chloride (1 g, 9.01 mmol) are initially introduced, and ethanol (absolute, 40 ml) is added. Sodium borohydride (1.33 g, 35.157 mmol) is subsequently added in portions with ice cooling. The reaction mixture is stirred at RT for 2 hours, then again cooled using an ice bath, and sodium borohydride (0.45 g, 11.895 mmol) is again added. The mixture is stirred overnight at RT.

출처