반응 #2254169

ord-458eca3c21d8400f9dcbc45757647934

반응 방정식

Cl
hydrochloric acid
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.Cl
Oxycodone hydrochloride
ClCCl
Methylene chloride
O=C([O-])[O-].[Na+].[Na+]
sodium carbonate
→
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314
oxycodone

반응물

Cl
hydrochloric acid
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.Cl
Oxycodone hydrochloride
ClCCl
Methylene chloride
—
hydrochloride salt
O=C([O-])[O-].[Na+].[Na+]
sodium carbonate

시약

없음

용매

O
water

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    추출to extract the formed oxycodone free base
  2. 2
    건조The obtained organic layer was dried over sodium sulfate and methylene chloride
  3. 3
    기타was evaporated
  4. 4
    기타evaporator
  5. 5
    기타The obtained oxycodone free base was purified by crystallization

실험 절차

The free base of oxycodone was prepared from its hydrochloride salt by the following method: Oxycodone hydrochloride was dissolved in water and sodium carbonate was added in the amount required to neutralize hydrochloric acid. Methylene chloride was added in order to extract the formed oxycodone free base. The obtained organic layer was dried over sodium sulfate and methylene chloride was evaporated using rotary evaporator. The obtained oxycodone free base was purified by crystallization.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09044398B2uspto-grants-2015_06