반응 #2254156

반응 방정식

2-amino-3-bromo-5-chlorobenzoic acid

phosgene

→

title compound

수율 114.2%

8-Bromo-6-chloro-1H-benzo[d][1,3]oxazine-2,4-dione

수율 114.2%

용매

dioxane

반응 조건

후처리

1. 1
   농축concentrated in vacuo
2. 2
   기타The resulting solid was crushed
3. 3
   기타further dried in vacuo

실험 절차

To a solution of 2-amino-3-bromo-5-chlorobenzoic acid (10.0 g, 39.9 mmol) in dioxane (170 mL) was added phosgene (20% in toluene, 42.0 mL, 79.9 mmol) over a period of 15 min. The reaction was stirred at room temperature for 48 h and then concentrated in vacuo. The resulting solid was crushed and further dried in vacuo to yield the title compound (12.6 g, 114%), which was used in the following step without further purification.

출처