반응 #2252

반응 방정식

3-dimethylamino-1-(2-chloro-4-pyridyl)-2-propen-1-one

3-trifluoromethylphenyl-guanidine nitrate

sodium hydroxide

→

N-(3-trifluoromethyl-phenyl)-4-(2-chloro-4-pyridyl)-2-pyrimidineamine

용매

2-propanol

반응 조건

후처리

1. 1
   여과filtered
2. 2
   세척is washed with 2-propanol and water
3. 3
   기타dried at 50° under HV

실험 절차

150 mg (0.71 mmol) of 3-dimethylamino-1-(2-chloro-4-pyridyl)-2-propen-1-one are suspended in 1.5 ml of 2-propanol. 190 mg (0.712 mmol) of 3-trifluoromethylphenyl-guanidine nitrate and 31 mg (0.783 mmol) of sodium hydroxide are added and the reaction mixture is stirred for 18 h under RF. It is then cooled to RT and filtered, and the material retained on the filter is washed with 2-propanol and water and dried at 50° under HV to give N-(3-trifluoromethyl-phenyl)-4-(2-chloro-4-pyridyl)-2-pyrimidineamine;

출처