반응 #2245

반응 방정식

3-(4-pyridinylamino)-1,2-benzisoxazole

methyl bromoacetate

→

title compound

수율 70.0%

[4-(3-Benzo[d]isoxazolylimino)-1-(4H)-pyridinyl]-acetic acid methyl ester hydrobromide

수율 70.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for one hour
3. 3
   여과the precipitated product was collected by filtration
4. 4
   세척The white solid was washed with diethyl ether
5. 5
   기타dried under vacuum

실험 절차

A mixture of 3-(4-pyridinylamino)-1,2-benzisoxazole (0.9 g, 4.3 mmol) and methyl bromoacetate (0.44 mL, 1.1 eq) in acetonitrile (25 mL) was heated at reflux for one hour. The mixture was then allowed to cool to room temperature and the precipitated product was collected by filtration. The white solid was washed with diethyl ether and dried under vacuum to provide the title compound (1.1 g, 70%), mp 235-236° C.

출처