반응 #2239

반응 방정식

N-(3-hydroxy-4-methoxybenzenesulphonyl)- 1,2-dihydroindole

3-phenoxypropylbromide

cesium carbonate

→

title compound

수율 86.8%

N-[3-(Phenoxypropoxy)-4-methoxybenzenesulphonyl]-1,2-dihydroindole

수율 86.8%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   기타The solvent was removed in vacuo
2. 2
   기타the residue partitioned between dichloromethane (30 ml) and water (15 ml)
3. 3
   세척The organic phase was washed with brine (15 ml)
4. 4
   건조then dried over magnesium sulphate
5. 5
   농축concentrated in vacuo
6. 6
   기타The residue was purified
7. 7
   세척eluting with dichloromethane

실험 절차

A solution of N-(3-hydroxy-4-methoxybenzenesulphonyl)- 1,2-dihydroindole (0.2 g) and 3-phenoxypropylbromide (0.15 g) in N,N-dimethylformamide (20 ml) was treated with cesium carbonate (0.3 g) and heated at 75° C. overnight. The solvent was removed in vacuo and the residue partitioned between dichloromethane (30 ml) and water (15 ml). The organic phase was washed with brine (15 ml) then dried over magnesium sulphate and concentrated in vacuo. The residue was purified using column chromatography eluting with dichloromethane to yield the title compound as a white solid (0.25 g).

출처