반응 #220958

반응 방정식

(4-Hydroxyphenethyl) alcohol

hydrobromic acid

→

product

수율 92.0%

4-(2-Bromoethyl)phenol

수율 92.0%

용매

water

반응 조건

후처리

1. 1
   온도After being cooled
2. 2
   추출extracted with ethyl acetate
3. 3
   세척The extracts were washed with water
4. 4
   기타dried
5. 5
   농축concentrated in vacuo
6. 6
   기타to give a raw product
7. 7
   기타Purification by flash chromatography (heptane/ethyl acetate 9:1)

실험 절차

(4-Hydroxyphenethyl) alcohol (1.50 g, 0.01086 mol) and 48 wt. % hydrobromic acid (10 ml) were heated at 100° C. for 1.5 h. After being cooled, the reaction mixture was poured into water and extracted with ethyl acetate. The extracts were washed with water, dried and concentrated in vacuo to give a raw product. Purification by flash chromatography (heptane/ethyl acetate 9:1) gave a pure product (2.01 g, 92%). 1H NMR (400 MHz, DMSO-d6): 2.99 (2H, t, 3J=7.4 Hz), 3.63 (2H, t, 3J=7.4 Hz), 6.68 (2H, d, 3J=8.5 Hz), 7.05 (2H, d, 3J=8.3 Hz), 9.24 (1H, s, —OH).

출처